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动物实验系列产品-选购指南

作者:翌圣生物科技(上海)股份有限公司 2024-03-11T00:00 (访问量:41941)

 

人类疾病的发展十分复杂,以人本身作为实验对象来深入探讨疾病发生机制,推动医药学的发展来之缓慢。借助动物模型的间接研究,可避免在人体上进行实验所带来的风险和伦理问题,可以有意识地改变那些在自然条件下不可能或不易排除的因素,以便更准确地观察模型的实验结果并与人类疾病进行比较研究,有助于科研者更方便有效地认识人类疾病的发生发展规律,研究防治措施。


翌圣生物提供多种类型的造模产品,包括结肠炎、胰腺炎、糖尿病和高血压等,详细信息如下表。

 

 

<点击查看详情>

 

 

 

 

 

 

客户案例

 01

DSS(Cat# 60316ES)

——含硫量16-20%,游离硫<0.2%,模拟人UC模型,安全高效

 

客户1:

 

客户来源:南京农业大学

动物类型:C57BL/6小鼠

造模方法:3% (w/v) DSS自由饮用7天

引用自:doi.org/10.1016/j.jnutbio.2020.108438

 

 

客户2:

 

客户来源:暨南大学

动物类型:BALB/c小鼠

造模方法:

1. 10 mg/kg AOM处理小鼠后用纯水自由饮1周;

2. 2.5%(w/v)DSS自由饮用1周,换纯水自由饮用2周

3. 步骤2重复3次。

引用自:doi: 10.3389/fphar.2020.586885

 

02

雨蛙素(Cat# 60321ES)

——十肽分子形式,纯度(HPLC)≥97%

 

客户3:

 

客户来源:上海交通大学医学院

实验动物:Balb/c小鼠

造模方法:以1小时间隔腹腔注射7次50 μg/kg雨蛙素,并在最后一次同时注LPS (10 mg/kg)诱导SAP。

引用自:doi.org/10.1016/j. ebiom.2022.103959

 

03

STZ(Cat# 60256ES)

客户4:

 

客户来源:华中科技大学同济医学院

引用自:DOI: 10.1021/acsami.1c24569

 

 

 

部分客户文献

 

[1] Li Zhao, Fei Wang,Zhengwei Cai,et al.Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis[J].chemical engineering journal.424(2021)130464.IF=16.744

[2] Lingjun Tong, Haining Hao, Zhe Zhang,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics.2021; 11(17): 8570-8586 IF=11.556

[3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245

[4] Jingjing Gan, Yuxiao Liu, Lingyu Sun,et al.Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment[J].Applied Materials Today.2021 Dec;25:101231 IF=10.041

[5] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423

[6] Xi Z, Ahmad E, Zhang W, et al. Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery. J Control Release. 2022;342:1-13. doi:10.1016/j.jconrel.2021.11.045.IF=9.776
[7] Xu Z, Liu Y, Ma R, et al. Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration. ACS Appl Mater Interfaces. 2022;14(12):14059-14071. doi:10.1021/acsami.1c24569.IF=9.229
[8] He R, Shi J, Xu D, et al. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer. Cancer Lett. 2022;538:215693. doi:10.1016/j.canlet.2022.215693.IF=8.679
[9] Zhang L, Shi J, Du D, et al. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. EBioMedicine. 2022;78:103959. doi:10.1016/j.ebiom.2022.103959.IF=8.143

[10]Xuan Zhang, Xia Gao, Xiangzhou Yi, et al. Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis[J]. Materials Today Bio.2024, 25100965. IF=8.2

 

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