NDEL1 (phospho S242) Peptide
产品名称： NDEL1 (phospho S242) Peptide
英文名称： NDEL1 (phospho S242) Peptide
产品编号： P1362
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of NDEL1 .
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S242 of human NDEL1 .
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.
Hayashi MA, Portaro FC, Bastos MF, Guerreiro JR, Oliveira V, Gorrao SS, Tambourgi DV, Sant'Anna OA, Whiting PJ, Camargo LM, Konno K, Brandon NJ, Camargo AC.Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3828-33. Epub 2005 Feb 23.
- 2.
- 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A.Nat Genet. 2003 Jul;34(3):274-85.
- 3.
- DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Morris JA, Kandpal G, Ma L, Austin CP.Hum Mol Genet. 2003 Jul 1;12(13):1591-608.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of NDEL1 (phospho S242) polyclonal antibody (Cat # PAB0549) in HepG2 cell line lysate (35 ug/lane).Phospho-NDEL1-pS242 (arrow) was detected using the purified polyclonal antibody (1 : 1450 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with NDEL1 (phospho S242) polyclonal antibody (Cat # PAB0549) which was peroxidase-conjugated to the secondary antibody followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 81565
- Protein Accession#:
- NP_110435;Q8TAR7
- Gene Name:
- NDEL1
- Gene Alias:
- DKFZp451M0318,EOPA,MITAP1,NUDEL
- Gene Description:
- nudE nuclear distribution gene E homolog (A. nidulans)-like 1
- Omim ID:
- 607538
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
- Other Designations:
- NUDE-like protein,endooligopeptidase A,mitosin-associated protein MITAP1,nudE nuclear distribution gene E homolog like 1