FITC标记的蛋白酶激活复合物亚基2抗体
产品名称： FITC标记的蛋白酶激活复合物亚基2抗体
英文名称： Anti-PSME2/FITC
产品编号： HZ-19576R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PSME2/FITC Conjugated antibody
FITC标记的蛋白酶激活复合物亚基2抗体
| 英文名称 | Anti-PSME2/FITC |
| 中文名称 | FITC标记的蛋白酶激活复合物亚基2抗体 |
| 别 名 | 11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28B; PA28beta; Proteasome (prosome macropain) activator subunit 2 (PA28 beta); Proteasome (prosome macropain) activator subunit 2; Proteasome activator 28 beta; Proteasome activator 28 subunit beta; Proteasome activator complex subunit 2; Proteasome activator hPA28 subunit beta; Proteasome activator subunit 2; PSME 2; PSME2; PSME2_HUMAN; REG beta; REG-beta; REGbeta. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSME2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008] Function: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Subunit: Heterodimer of PSME1 and PSME2, which forms a hexameric ring. Similarity: Belongs to the PA28 family. Database links: Entrez Gene: 5721 Human Entrez Gene: 509857 Cow Entrez Gene: 480258 Dog Entrez Gene: 101836765 Hamster Entrez Gene: 100051729 Horse Entrez Gene: 19188 Mouse Entrez Gene: 397522 Pig Entrez Gene: 100362709 Rat Entrez Gene: 100364216 Rat Entrez Gene: 29614 Rat Entrez Gene: 30647 Zebrafish Omim: 602161 Human SwissProt: Q5E9G3 Cow SwissProt: Q9UL46 Human SwissProt: P97372 Mouse SwissProt: Q863Z0 Pig SwissProt: Q63798 Rat Unigene: 434081 Human Unigene: 512410 Human Unigene: 371573 Mouse Unigene: 127779 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
26S蛋白酶体是由2个复合物、一个20S核和一个19S调节剂组成的高度有序的多催化蛋白酶复合物。20S核由4个环组成，其中有28个不相同的亚基；2个环由7个α亚基组成，2个环由7个β亚基组成。19S调节器由一个包含6个ATPase亚基和2个非ATPase亚基的基座和一个最多包含10个非ATPase亚基的盖子组成。蛋白酶体以高浓度分布在真核细胞中，在非溶酶体途径中以ATP/泛素依赖的过程切割肽。一种修饰的蛋白酶体，免疫蛋白酶体的基本功能，是I类MHC肽的加工。免疫蛋白酶体包含一个替代的调节器，被称为11S调节器或PA28，取代了19S调节器。已经鉴定出11S调节子的三个亚基（α，β和γ）。该基因编码11S调节子的β亚基，这是由γ干扰素诱导的两个11S亚基之一。三β和三α亚基结合形成异六聚体环。在4, 5, 8、10和13染色体上已鉴定出六个假基因。[ RefSeq，JUL 2008 ]