Anti-MDM2 Polyclonal Antibody

品牌：solarbio | 货号：K106576P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K106576P-50ul	solarbio	50ul	960.00元
K106576P-100ul	solarbio	100ul	1600.00元

英文名称 Anti-MDM2 Polyclonal Antibody
别名 ACTFS;hdm2;HDMX;E3 ubiquitin-protein ligase Mdm2
应用 WB
稀释比例 WB 1:3000.
交叉反应 Human Mouse Rat
蛋白分子量 48kDa
Gene ID 4193
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human MDM2
性状 液体
Public Immunogen Range A synthetic peptide of human MDM2
Subcellular Locations Nucleus
Swiss Prot Q00987
克隆类型 Polyclonal Antibody
背景资料 Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX.

英文名称	Anti-MDM2 Polyclonal Antibody
别名	ACTFS;hdm2;HDMX;E3 ubiquitin-protein ligase Mdm2
应用	WB
稀释比例	WB 1:3000.
交叉反应	Human Mouse Rat
蛋白分子量	48kDa
Gene ID	4193
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human MDM2
性状	液体
Public Immunogen Range	A synthetic peptide of human MDM2
Subcellular Locations	Nucleus
Swiss Prot	Q00987
克隆类型	Polyclonal Antibody
背景资料	Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX.