PTK2B polyclonal antibody
产品名称： PTK2B polyclonal antibody
英文名称： PTK2B polyclonal antibody
产品编号： PAB18133
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PTK2B.
- Immunogen:
- A synthetic peptide corresponding to human PTK2B.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to PTK2B.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.
Hodges RR, Rios JD, Vrouvlianis J, Ota I, Zoukhri D, Dartt DA.Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3352-9.
- 2.
- The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes.
McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR.J Biol Chem. 2004 Mar 26;279(13):12009-19. Epub 2003 Dec 29.
- 3.
- G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.
Shi CS, Sinnarajah S, Cho H, Kozasa T, Kehrl JH.J Biol Chem. 2000 Aug 11;275(32):24470-6.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from K-562 cells treated with UV (15 mins), using PTK2B polyclonal antibody (Cat # PAB18133).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 2185
- Protein Accession#:
- Q14289
- Gene Name:
- PTK2B
- Gene Alias:
- CADTK,CAKB,FADK2,FAK2,FRNK,PKB,PTK,PYK2,RAFTK
- Gene Description:
- PTK2B protein tyrosine kinase 2 beta
- Omim ID:
- 601212
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- CAK beta,OTTHUMP00000128275,OTTHUMP00000162913,calcium-dependent tyrosine kinase,cell adhesion kinase beta,focal adhesion kinase 2,proline-rich tyrosine kinase 2,protein kinase B,protein tyrosine kinase 2 beta,related adhesion focal tyrosine kinase
- Interactome
