Uniprot ID:Q92800
Species Reactivity:Human,Mouse
Antibody type:Polyclonal Antibody
Aliases:ENX-2,Enhancer of zeste homolog 1,EZH1,KIAA0388Raised in:Rabbit
Background\Function :Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Stroage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity:Antigen Affinity Purified
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