BRCA1 monoclonal antibody-抗体-抗体-生物在线
亚诺法生技股份有限公司（Abnova)
BRCA1 monoclonal antibody

BRCA1 monoclonal antibody

商家询价

产品名称： BRCA1 monoclonal antibody

英文名称： BRCA1 monoclonal antibody

产品编号： MAB2170

产品价格： null

产品产地： 台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)
  • 联系人 :
  • 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
  • 邮编 : 11493
  • 所在区域 : 台湾
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  • 邮箱 : sales@abnova.com.tw
进入展台

  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant BRCA1.
  • Immunogen:
  • Recombinant GST fusion protein corresponding to amino acids 341-748 of BRCA1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Storage Buffer:
  • In PBS, pH 7.4
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1-10 ug/mL)
    Immunoprecipitation (1-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 672
  • Gene Name:
  • BRCA1
  • Gene Alias:
  • BRCAI,BRCC1,IRIS,PSCP,RNF53
  • Gene Description:
  • breast cancer 1, early onset
  • Gene Summary:
  • This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 1,breast and ovarian cancer susceptibility protein 1
  • Related Disease

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