FITC标记的神经元突触膜胞外分泌调节蛋白2抗体-抗体-抗体-生物在线
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FITC标记的神经元突触膜胞外分泌调节蛋白2抗体

FITC标记的神经元突触膜胞外分泌调节蛋白2抗体

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产品名称： FITC标记的神经元突触膜胞外分泌调节蛋白2抗体

英文名称： Anti-RIM2/FITC

产品编号： HZ-11357R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-RIM2/FITC Conjugated antibody 

FITC标记的神经元突触膜胞外分泌调节蛋白2抗体

 

产品编号 bs-11357R-FITC
英文名称 Anti-RIM2/FITC
中文名称 FITC标记的神经元突触膜胞外分泌调节蛋白2抗体
别    名 Non small cell lung cancer RimL3a protein; Rab3 interacting molecule 2; RAB3IP3; Regulating synaptic membrane exocytosis protein 2; Rims2; RIMS2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 160kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIM2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis (1-2). Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing (3). Rim1 is expressed near the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3, located on synaptic vesicles (4). Therefore, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5). Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis (3). Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion (6).

Function:
RIM2 is a rab effector involved in exocytosis. It may act as scaffold protein. It is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP dependent manner. 

Subunit:
Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 (By similarity).

Subcellular Location:
Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity).

Similarity:
Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger. 
Contains 1 PDZ (DHR) domain. 
Contains 1 RabBD (Rab-binding) domain. 

Database links:
UniProtKB/Swiss-Prot: Q9UQ26.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

rab3，神经/神经内分泌特异的Rab家族的成员，参与Ca2+调节的胞吐作用（1-2）。通过控制招聘到分泌囊泡释放池在质膜中的抑制能力的rab3功能。RIM（Rab3相互作用的分子），为rab3s一个假定的效应蛋白，是由一个氨基末端的锌指结构域和羧基末端PDZ和C2结构域。RIM两变种存在，RIM1和因子，通过选择性剪接产生（3）。RIM1表示附近的活动区在突触处，其中的相互作用在一个Rab3 GTP依赖性，位于突触囊泡（4）。因此，RIM作为rab3依赖形成突触质膜之间的GTP依赖的复杂调节突触囊泡融合和停靠的突触囊泡（5）。两RIM1和因子可以绑定到gefii营，这是在调节胞吐营的直接目标并负责cAMP、PKA依赖的胞吐作用（3）。RIM也定位在INS-1E细胞和胰岛β细胞膜。RIM的rab3结合域增强葡萄糖刺激分泌细胞和透化细胞Ca2+刺激胞吐作用，这表明RIM也可能在胰岛素的分泌起调节作用（六）。