DDEF2 polyclonal antibody (A01)
产品名称： DDEF2 polyclonal antibody (A01)
英文名称： DDEF2 polyclonal antibody (A01)
产品编号： H00008853-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant DDEF2.
- Immunogen:
- DDEF2 (NP_003878, 909 a.a. ~ 1006 a.a) partial recombinant protein with GST tag.
- Sequence:
- RGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.89 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- DDEF2 polyclonal antibody (A01), Lot # 060501JCS1 Western Blot analysis of DDEF2 expression in SJCRH30 ( Cat # L027V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 8853
- GeneBank Accession#:
- NM_003887
- Protein Accession#:
- NP_003878
- Gene Name:
- ASAP2
- Gene Alias:
- AMAP2,CENTB3,DDEF2,FLJ42910,KIAA0400,PAG3,PAP,Pap-alpha,SHAG1
- Gene Description:
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
- Omim ID:
- 603817
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- PYK2 C terminus-associated protein,centaurin, beta 3,development and differentiation enhancing factor 2
- Gene Pathway