FITC标记的FAM65B蛋白抗体
产品名称： FITC标记的FAM65B蛋白抗体
英文名称： Anti-FAM65B/FITC
产品编号： HZ-12370R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FAM65B/FITC Conjugated antibody
FITC标记的FAM65B蛋白抗体
| 英文名称 | Anti-FAM65B/FITC |
| 中文名称 | FITC标记的FAM65B蛋白抗体 |
| 别 名 | Ab2 162; C6orf32; DIFF48; FA65B_HUMAN; Fam65b; KIAA0386; PL48; Protein FAM65B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 发育生物学 干细胞 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 118kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM65B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf32 gene product has been provisionally designated C6orf32 pending further characterization. Function: Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation. Subcellular Location: Mitochondrion and Cytoplasm; cytoskeleton. Cell projection; filopodium. Detected in cellular filopodia. Tissue Specificity: Isoform 1 is present in the brain. Isoform 2 is expressed during differentiation of fetal primary myoblasts. Also shows marked expression during cytotrophoblast differentiation. Post-translational modifications: Asn-41 was reported (PubMed:16335952) to be N-glycosylated; however as this position is probably not extracellular, the in vivo relevance is not proven. Similarity: Belongs to the FAM65 family. Database links: UniProtKB/Swiss-Prot: Q9Y4F9.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在人类基因组的近6%中，6号染色体包含1亿7000万个碱基对序列中大约1200个基因。6号染色体q臂部分缺失与早期发病的肠癌有关，提示存在癌症易感位点。迟发性皮肤卟啉症通过HFE基因与6号染色体相关联，当HFE基因突变时，它使个体易于发展这种卟啉症。值得注意的是，与帕金森病相关的PARK2基因以及编码主要组织相容性复合蛋白的基因也位于第6染色体上，这些蛋白是免疫系统的关键分子组成部分并且决定了风湿病的易感性。Stutkle综合征、21羟化酶缺乏症和枫糖浆尿病也与6号染色体上的基因有关。在6号染色体Q臂上发现了双相情感障碍易感基因位点。C6OFF32基因产物已暂时指定为C6OF32，有待进一步鉴定。