Human Growth Factors & Cytokines
Recombinant Human IGF-BP3





 





		Synonyms :
Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein



		Description :
IGF-BP3 is a 30 kDa cysteine-rich secreted protein.  It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets.  In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity.  Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.  The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.  Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.



		Catalog #:
100-08



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7.  The expected ED50 for this effect is ≤ 0.2 μg/ml in presence of 15 ng/ml of human IGF-II.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK 



		PubMed Link :
IGF+AND+Binding+AND+Protein-3


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
25μg
$195 
 


 



        Size C
1mg
$3000 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.