SPRED1 polyclonal antibody
产品名称： SPRED1 polyclonal antibody
英文名称： SPRED1 polyclonal antibody
产品编号： PAB16582
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SPRED1.
- Immunogen:
- A synthetic peptide corresponding to internal region 14 amino acids of human SPRED1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.
Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M.Oncogene. 2006 Oct 5;25(45):6056-66. Epub 2006 May 1.
- 2.
- Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.Nature. 2001 Aug 9;412(6847):647-51.
- 3.
- Inhibition of angiogenesis by a mouse sprouty protein.
Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL.J Biol Chem. 2001 Feb 9;276(6):4128-33. Epub 2000 Oct 26.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of SPRED1 in human brain tissue lysate with SPRED1 polyclonal antibody (Cat # PAB16582) at (A) 1 and (B) 2 ug/mL .
- Entrez GeneID:
- 161742
- Protein Accession#:
- NP_689807
- Gene Name:
- SPRED1
- Gene Alias:
- FLJ33903,NFLS
- Gene Description:
- sprouty-related, EVH1 domain containing 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq
- Other Designations:
- EVH1/Sprouty domain containing protein,sprouty-related protein 1 with EVH-1 domain,suppressor of Ras/MAPK activation
- Gene Pathway